The Commerce and Industries Building was located on the south side of El Prado, immediately east of the Panama-California Exposition's Foreign and Domestic Arts Building. The extremely ornate eclectic Renaissance structure featured two tile-roofed entrance bays and a heavily ornamented corner tower. The building's entrances were based on the design of the Casa Consistorial, in Palma de Mallorca, Spain; and contained triple-arched vestibules above which were located ornate balconies with intricate wrought-iron railings. Tile-roofed overhangs, featuring brightly colored friezes of blue, red, green, and gold, extended over both entrances, and were supported by caryatids in the form of nude women. The Rococo-ornamented corner tower contained two semi-circular iron-railed balconies, topped by a decorative cornice and ornate finials. The rear portion of the building was less heavily ornamented, to harmonize with the adjacent Foreign and Domestic Arts Building, and overlooked a small park and Spanish Canyon, which extended to the south. The interior of the building housed numerous commercial and industrial exhibits, displayed by domestic firms.